So I’m basically doing an autism deep-dive into endocrinology at the moment and I came across this study, which suggests that
There have been good results in recent research to inhibit the generator of pulsatile secretion of GnRH necessary for ovulation by using melatonin in a new type of oral contraceptive.
As far as I understand from this article, GnRH basically stimulates biological hormone production (testosterone & LH in biological men; progesterone and estrogen in biological women).
If melatonin reduces GnRH production to such a level that it may even be used as a contraceptive, I cannot help but wonder, if any of you remember any supplementary (gender affirming) effects if you have taken melatonin before or during replacement hormone therapy?
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All I remember is that it made me wake up feeling like I was slightly hungover.
If you’d like to say how much did you take?
I honestly don’t remember. It was 5 or so years ago. From memory, they were small brown gel caps, and I initially took 2 of an evening, but moved down to 1, before stopping. Can’t remember the dose in each cap
Thank you!
Yeah, we took too much in vegan gummies (just two) and gosh we were so depressed the next day. We stopped after that.
no, but melatonin did increase my parasomnias and likelihood of discomfort if I didn’t fall asleep quickly enough, so I avoided it pre-transition (I guess I still do, but my parasomnias and nightmares are far less common since I started estrogen).
If you do take it, take as little as is effective. We took too much at least once and it made us feel depressed. Start small and work your way up a very little at a time if, and only if you need more.
