So I’m basically doing an autism deep-dive into endocrinology at the moment and I came across this study, which suggests that
There have been good results in recent research to inhibit the generator of pulsatile secretion of GnRH necessary for ovulation by using melatonin in a new type of oral contraceptive.
As far as I understand from this article, GnRH basically stimulates biological hormone production (testosterone & LH in biological men; progesterone and estrogen in biological women).
If melatonin reduces GnRH production to such a level that it may even be used as a contraceptive, I cannot help but wonder, if any of you remember any supplementary (gender affirming) effects if you have taken melatonin before or during replacement hormone therapy?
If you do take it, take as little as is effective. We took too much at least once and it made us feel depressed. Start small and work your way up a very little at a time if, and only if you need more.