So I’m basically doing an autism deep-dive into endocrinology at the moment and I came across this study, which suggests that
There have been good results in recent research to inhibit the generator of pulsatile secretion of GnRH necessary for ovulation by using melatonin in a new type of oral contraceptive.
As far as I understand from this article, GnRH basically stimulates biological hormone production (testosterone & LH in biological men; progesterone and estrogen in biological women).
If melatonin reduces GnRH production to such a level that it may even be used as a contraceptive, I cannot help but wonder, if any of you remember any supplementary (gender affirming) effects if you have taken melatonin before or during replacement hormone therapy?
no, but melatonin did increase my parasomnias and likelihood of discomfort if I didn’t fall asleep quickly enough, so I avoided it pre-transition (I guess I still do, but my parasomnias and nightmares are far less common since I started estrogen).