Estradiol monotherapy. Started HRT 3 months ago with 2mg Estradiol oral tablets. Have a doctor appointment in a few days and wanted to ask to double my oral prescription, split up 4mg into 4 doses sublingual every day. Not sure if my Estrogen levels are too high and my doctor will deny my request.

  • Pre-HRT Estrogen (TOTAL IA): 181 pg/mL
  • Pre-HRT Testosterone (Total IA): 246 ng/dL
  • Levels this week Estrogen Total IA: 438 pg/mL
  • Levels this week Testosterone Total IA 115 ng/dL

From what I understand I feel like I’m definitely not achieving Testosterone suppression. https://transfemscience.org/ recommends T levels around 10 ng/dL. But having E levels of 400 pg/mL is the right range for E.

Can I convince my doctor to double my dose if my E is already at >400 pg/mL?

Edit 01: I did not take my daily dose until after my blood was drawn. Blood draw was already 24+ hours since last oral dose.

Edit02: Thank you all for your responses. My doctor approved the prescription doubling. My idiot brain realized after the fact that I didn’t even need the doubling in the first place (I guess I get to stockpile now). I intended to follow the 0.5mg four times a day protocol shown here https://pubmed.ncbi.nlm.nih.gov/38130980/ . Really could have just cut my 2mg pills into four pieces.

  • WoodScientist@sh.itjust.worksEnglish
    3·
    30 days ago

    Sex development is so complicated.

    https://pmc.ncbi.nlm.nih.gov/articles/PMC2190741/

    We report herein a remarkable family in which the mother of a woman with 46,XY complete gonadal dysgenesis was found to have a 46,XY karyotype in peripheral lymphocytes, mosaicism in cultured skin fibroblasts (80% 46,XY and 20% 45,X) and a predominantly 46,XY karyotype in the ovary (93% 46,XY and 6% 45,X).