There is also gel, which I found worked fine even for monotherapy. The downside is you have to apply a lot, which is a pain.
Injections give you a peak and drop-off, which more closely resembles cis natural estrogen production. I don’t know for sure if that is beneficial, but saturation is a thing.
I was told sublingual is one of the worst forms of hrt at this point. Basically shots > pills > sublingual
Edit: after doing research, it sounds like sublingual is more potent but also less consistent. Now I’m wondering if I can take my pills sublingually or if it requires a different formulation.
sublingual has a much higher absorbtion rate than other methods, but also will deplete in your system much quicker, you peak in about 2-4 hours and are back to normal levels within 6-8 hours for most people, so if you want consistent levels with sublingual you need to take it like every 8 hours, or every 12 but 8 is better.
gels can be inconsistent in measurements, so your dose can vary, but it likely isnt a huge deal, sprays get around this much better.
injections are cool because i only have to think about it once a week.
sublingual can be effective but it requires taking a dose like every 8 hours for best results. no delivery method is best, just better in some ways, worse in others.
I was doing sublingual for a few years now and found it to be far more effective than taking the pills orally. It has a much higher bioavailability over oral, but can be a bit chaotic with how the estrogen levels spike throughout the day. Overall, at trough, my estradiol was fairly consistent and at good levels, but it was annoying to set alarms to take it so I have recently switched ROA.
![been doing injections a month now it's so much better [CW: Assumes Viewer is Transfem]](https://lemmy.blahaj.zone/pictrs/image/04e611cd-745d-4357-8ae4-87dfd5ec4199.webp){kind=link}
I don’t like needles tho (> _ <)… is it really that noticeable of a difference from sublingual?
There is also gel, which I found worked fine even for monotherapy. The downside is you have to apply a lot, which is a pain.
Injections give you a peak and drop-off, which more closely resembles cis natural estrogen production. I don’t know for sure if that is beneficial, but saturation is a thing.
I was told sublingual is one of the worst forms of hrt at this point. Basically shots > pills > sublingual
Edit: after doing research, it sounds like sublingual is more potent but also less consistent. Now I’m wondering if I can take my pills sublingually or if it requires a different formulation.
sublingual has a much higher absorbtion rate than other methods, but also will deplete in your system much quicker, you peak in about 2-4 hours and are back to normal levels within 6-8 hours for most people, so if you want consistent levels with sublingual you need to take it like every 8 hours, or every 12 but 8 is better.
gels can be inconsistent in measurements, so your dose can vary, but it likely isnt a huge deal, sprays get around this much better.
injections are cool because i only have to think about it once a week.
Wait really? I was told the opposite from pills/sublinguals. I’m just a giant baby and really hate needles…
That’s what I was told when I got my hrt.
sublingual can be effective but it requires taking a dose like every 8 hours for best results. no delivery method is best, just better in some ways, worse in others.
I was doing sublingual for a few years now and found it to be far more effective than taking the pills orally. It has a much higher bioavailability over oral, but can be a bit chaotic with how the estrogen levels spike throughout the day. Overall, at trough, my estradiol was fairly consistent and at good levels, but it was annoying to set alarms to take it so I have recently switched ROA.