If they’re fit, not too tired. Humans are some of the best distance runners in the animal kingdom, and we can walk virtually forever. And we can regulate our own body temperature by sweating. And we can carry some extra food and water with us. And we are capable of being excellent trackers as well. The joke in the op is about how humans used to hunt - by chasing an animal until it collapses of exhaustion. Some tribes still do this today