I tried many of those with no success, until tried Duloxetine and the response was optimal. Each persons has different reactions.

Duloxetine made me really tired. Fatigue to the deepest level. I tried for two months but did not ease, had to switch back to sertraline. Any anecdotes of similar? Anyone find a good one? Was trying to get off sertraline due to weight gain slowly over a long time.

My wife tried fluoxetine (Prozac), and it really impacted her libido and weight gain. She was also very drowsy, but that’s not listed. She’s now on bupropion (Wellbutrin) and is just living her best life. We were late 20’s when she started taking it so the libido impact is super important to us. The biggest thing she says about Wellbutrin is that it can cause a little irritability with alcohol, and she’s glad she didn’t start that at the same time as adderall since it’s kinda the same.

I’m glad Buproprion has few side effects from this chart.

However, for those considering it, here’s some missing side effects:

1. Can increase libido. (A lot.)
2. Can reduce weight. (A lot.)
3. Can reduce your appetite/eating. (A lot.)

I’m not saying these are pros or cons. Each person should assess how these side effects will affect their own situation.

Bupropion is interesting here. I’ve been on and off since I was literally a child. Last go-round I was on Effexor, Wellbutrin, and Adderall. Gained 40 lbs but I’m still not sure if that was the medication or I was on the medication because of life stress and it was the life stress. Would love to see more of these charts, I think it’s really well laid out and easy to read and compare.

Needs a column for “makes you feel like you are Being John Malkoviching as you linger behind your own eyes and watch another version of yourself interact with the world while being confused about who is actually controlling your vessel”, and put Bupropion at a 12.

If y’all have had really bad side-effects look into pharmacogenomic testing, it can help rule out bad medicines before you try them

I had one done a while ago and it marked a ton of medicines that I had already tried, (and had bad effects from) and a bunch I hadn’t tried yet. Since then, I’ve had much fewer bad experiences

Seems to be missing the entire MAOI class (moclobemide, selegiline, phenelzine, tranylcypromine, isocarboxazid), and most tricyclics (clomipramine, imipramine, nortriptyline, et al)

Had a doctor tell me I should never feel the antidepressant. Should be a background thing. Thought that was good advice.

Setraline leveled me the fuck out.

An off label use for Trazadone is as a sleep aid. At doses under 150 mg it doesn’t really work as an antidepressant but will make you drowsy. I’ve been prescribed it before as the first step before Ambien

Man, I wish we had these charts for all classes of medicines.

Is this chart actually used in prescribing patients? I find that concerning. I have abnormal metabolism on several of my CYP enzymes, plus I have other medications that are ligands of them as well.

For instance, there are people who have multiple gene copies of rapid metabolizing enzymes. They may not get any side effects, but may also not get any benefit.

An intermediate metabolizer may get a better response at lower doses and not have to worry about side effects at all.

Compared with someone who has two inactive copies of the primary metabolic enzyme, they may end up with significant side effects and no benefit at low doses.

The only way to know your metabolism is genetic testing. (Which they have studies for, and some insurances cover).

Tried a bunch of them, none really worked except for Venlafaxine. Had sexual dysfunktion which was an unacceptable side effect for me so I also quit them. This sucks.

Oddly enough for me, anti-depressants (zoloft currently) doesn’t work at all for me. Not even side effects, just… nothing.

Too early to make a decision though, probably just need to find the right antidepressant.

Yeah Mirtazapine fucked me up in the weight department