I found this chart on reddit some time ago, I thought to repost it here as well
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Needs a column for “makes you feel like you are Being John Malkoviching as you linger behind your own eyes and watch another version of yourself interact with the world while being confused about who is actually controlling your vessel”, and put Bupropion at a 12.
If y’all have had really bad side-effects look into pharmacogenomic testing, it can help rule out bad medicines before you try them
I had one done a while ago and it marked a ton of medicines that I had already tried, (and had bad effects from) and a bunch I hadn’t tried yet. Since then, I’ve had much fewer bad experiences
notes
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the one I did had a specific brand name but I don’t remember what it was. (It was a while ago) I’m pretty sure this is what it was though
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you might have to remind your doctor about it when they’re prescribing medications, this still isn’t very well known afaik
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this isn’t sponsored/paid/other bullshit, this is an actual recommendation (though I felt like one of those ‘ask your doctor if !@#$ is right for you’ american commercials the entire time writing it)
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Seems to be missing the entire MAOI class (moclobemide, selegiline, phenelzine, tranylcypromine, isocarboxazid), and most tricyclics (clomipramine, imipramine, nortriptyline, et al)
Oddly enough for me, anti-depressants (zoloft currently) doesn’t work at all for me. Not even side effects, just… nothing.
Too early to make a decision though, probably just need to find the right antidepressant.
Had a doctor tell me I should never feel the antidepressant. Should be a background thing. Thought that was good advice.
Setraline leveled me the fuck out.
It’s kinda funny how much medicines’ effects can vary from person to person, I tried sertraline and had absolutely no difference, whereas my mother and my sister take it and it works for them
May I ask, what do you mean it leveled you out?
Anger flare ups stemming from depression. Took cognitive behavioral therapy for a time until I could learn the coping skills. Still take the setraline.
Have noticed when I wheen off/am off it am more prone to those flare ups. They don’t happen outright, I just notice them more prominently.
Man, I wish we had these charts for all classes of medicines.
An off label use for Trazadone is as a sleep aid. At doses under 150 mg it doesn’t really work as an antidepressant but will make you drowsy. I’ve been prescribed it before as the first step before Ambien
I thought it’s use as an antidepressant was completely discontinued because of that.
¯\_(ツ)_/¯
I’m not a doctor, just need help sleeping sometimes
Tried a bunch of them, none really worked except for Venlafaxine. Had sexual dysfunktion which was an unacceptable side effect for me so I also quit them. This sucks.
I’m on Venlafaxine and the sexual dysfunction side effect does subside over time (months), at least that was my experience.
Had the same side effect with Citalopram, Sertraline and one or two others I tried, but I can’t remember. Basically that was the only effect I noticed until I tried Venlafaxine. All this happened in about 9 months because antidepressants usually need some time to properly get in/out the system. So maybe I’m just very sensitive in that regard.
Hmm maybe, it was noticeably improved after 9 months for me.
tbh I’m not dealing that long with side effects if I can’t handle them. But good for you.
Venlafaxine almost killed me which is fun :^)
Same here. Wasn’t funny at all.
Hey twinsies!
Is this chart actually used in prescribing patients? I find that concerning. I have abnormal metabolism on several of my CYP enzymes, plus I have other medications that are ligands of them as well.
For instance, there are people who have multiple gene copies of rapid metabolizing enzymes. They may not get any side effects, but may also not get any benefit.
An intermediate metabolizer may get a better response at lower doses and not have to worry about side effects at all.
Compared with someone who has two inactive copies of the primary metabolic enzyme, they may end up with significant side effects and no benefit at low doses.
The only way to know your metabolism is genetic testing. (Which they have studies for, and some insurances cover).
Yeah Mirtazapine fucked me up in the weight department
Same here. Soon as I stopped, the weight stopped!
Now I know y I dont have that much of a Craving for Sex anymore. Thought I just got old.
Antidepressants get such a bad rep, they’re truly amazing
Removed by mod
Sorry mate.
Writing like this.
Doesn’t make you look.
More knowledgeable.
This is a very complex topic that affects people’s entire lives, please don’t continue to make the mistake of thinking this is as black and white as “just take shrooms”.
Like my life?
Struggling with depression, throwing out all my meds. Starting with microdosing and feeling improvement inside of a week?
Continuing for 4 years like this.
Advising others. 4 success stories. 0 ‘fails’.
Speaking to nurses, Docs…
2 science degrees.
Ya, I’m good with my knowledge and experience.
So I have never had depression but I am aware that Sertraline is probably the most common. Is there some higher rate of effectiveness it has over the less alternatives with less side effects? Is it just that it’s cheaper?
The issue with mental health and medications is that different root causes can create different symptoms in different people, and different medications have different effects in different people. The understanding of what those root causes even are is very limited, let alone trying to figure out what the root causes are in a specific person.
We know that certain medications have certain effects on symptoms, generally speaking, but identifying which one, at which dose, suits that specific person with a collection of reported symptoms that look like depression or anxiety or whatever, often in combination, is trial and error.
Of course, in the US, where healthcare is “fuck you, I got mine,” cost does also play a role. Shouldn’t, but does. Another thing to take into account is what other medications you’re taking, and whether they interact poorly with one another.
Sertraline is the generic for Zoloft, and it’s been FDA-approved since 1991. That’s a good long time, and if you’re going to prescribe an SSRI, it makes sense to give more weight to something that has a long history, for the sake of both effectiveness and side effects.
Research, and more anecdotal than I can count, including a number of my own, shows psilicybin (I use ground magic mushrooms) at slightly-less-than ‘feel high’ doses 4 days a week (aka micro or threshold dose) equals, or surpasses efficacy of any of that list.
No side effects.
Shit works, and you don’t have to “get high” and lose your moral compass, etc.
If you abuse psilicybin, it just stops working. You really can’t get addicted to it at all. Also there is NO ‘lethal dose’. You can’t die from it.
Fuck Rx!
I would but it’s illegal here and in the same category as heroin or coke for some idiotic reason.
Fuuuck. I literally just ordered 28g of mushrooms I’ll dose into 300mg capsules.
In general I feel the same about an occasional dose of ketamine. Any time I feel a general malaise, ketamine blasts all the cobwebs out and gives me a new lease of life for quite a long time.
There’s some conventional thinking that it’s slightly more “activating” and has fewer side effects than the other cheap SRIs, escitalopram being still under patent.
i take agomelatine and have tried SSRIs and i will never go back after agomelatine.
