There are obviously exceptions, hence why I said often instead of always. Think larger scale and/or involving fixed objects and cardinal directions tend to be logical, for example:

• Install the equipment in the western plant room.

• Please set up the workstation near the power point on the western wall of the room.

• Come in via Foo Rd, when you get to the intersection with Bar Rd turn west.

• My desk is in the south western corner of the office.

• Walk west along the ridge from the carpark, then once you reach the giant boulder take the northern spur down to the river.