On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
I think you would pick a north depending on your place of origin. Probably from either their own planet or, more likely, their own galaxy.
But when you get to another galaxy you’d probably have to pick again. Galaxies aren’t all oriented the same way but they do roughly spin at the same speed. So, just like earth, from a certain point of view everything spins around the north south axle. But that does not have to line up to your home galaxy. And even if they did, it might spin the other way around. Much like venus spins in the opposite direction of the rest of the planets in our solar system.
What I’m trying to say is that using a universal North is completely impractical for intergalactic space travel. So you’d probably use a local system. And where that’s not possible, you’d probably use your point of origin for orientation.