If you can’t handle them without sedative then you can’t administer the sedative in the first place. If you can handle them well enough to give them a sedative shot then you could just give them the vaccine shot you wanted to in the first place
I mean cats can be a lot harder to handle after you poke them. What if you need to give multiple vaccines? What if you need to draw blood? What if you need to touch other parts of their body to look for issues? What if you need to examine their mouth? Some cats will put up with it, some (a lot) will not. It’s a lot safer and less stressful for everyone if you just use a sedative when needed.
If you can’t handle them without sedative then you can’t administer the sedative in the first place. If you can handle them well enough to give them a sedative shot then you could just give them the vaccine shot you wanted to in the first place
I mean cats can be a lot harder to handle after you poke them. What if you need to give multiple vaccines? What if you need to draw blood? What if you need to touch other parts of their body to look for issues? What if you need to examine their mouth? Some cats will put up with it, some (a lot) will not. It’s a lot safer and less stressful for everyone if you just use a sedative when needed.