You can have 2 different keys DB on keepassXC with different passwords, you can even try to save them in separate remote locations. The key points are data interoperability over different devices and its portability over different services, because the worst thing that can happen is that your favourite app, from where you cannot use or move your credentials elsewhere (like the Steam Guard app for instance), one day might stop working suddenly leaving you unable to access your accounts.
I don’t like the thought of having my passwords and 2FA live in the same place - that seems to miss the point a bit.
You can have 2 different keys DB on keepassXC with different passwords, you can even try to save them in separate remote locations. The key points are data interoperability over different devices and its portability over different services, because the worst thing that can happen is that your favourite app, from where you cannot use or move your credentials elsewhere (like the Steam Guard app for instance), one day might stop working suddenly leaving you unable to access your accounts.