So I started oral estradiol 2mg and bicalutimide 50mg about 2 weeks ago. A week in, I started feeling these weird pains in my body. They felt like small stabbing pains that immediately dulled - almost like the pain of getting an injection, and were always in my legs, arms, or chest.

I asked my doctor about it, and he had no idea. He just said they weren’t a reported side effect of either med, and the only way to tell if it was the meds was to stop them.

I’m really paranoid about, like, fucking dying, so I stopped my medication 3 days ago and the pains have subsided. I was just wondering if anyone here has shared my experience. I’d like to know what the hell that was, and if it’s safe to continue treatment.

  • dandelionEnglish
    6·
    6 days ago

    See https://lemmy.blahaj.zone/post/14985192 and paging @will_steal_your_username@lemmy.blahaj.zone

    this seems similar to what she was describing, pain in legs after injecting estrogen

    EDIT: I should say, I’ve never experienced this, even when I was taking bicalutamide. I did have some sensations I would describe like a body buzz, but it was never painful (was pleasant, even).

    You might experiment with different doses and see if switching to spiro makes a difference. Might also try monotherapy, just see if any of those experiences are different.

    But yes, bioidentical estrogen should be totally safe, esp. if you are injecting it or using it transdermally. Oral is still safe, but it’s very spikey, and arguably not as great:

    Estradiol levels are found to rapidly rise on the order of ten times that of the peak of oral estradiol, then rapidly decline with an elimination half-life of a few hours (Kuhl, 2005).

    For that reason I wouldn’t recommend oral, even though it’s so popular. I would assume negative side effects like mood swings, slower and uneven testosterone suppression, and low average estradiol blood levels are more likely on oral. Still, lots of people are fine on oral so it’s more something for you to experiment with and see what works best for you.

    • VerilyFemmeOPEnglish
      5·
      6 days ago

      I should have specified in my post, but I was taking oral estrogen.

      • dandelionEnglish
        3·
        6 days ago

        Unclear whether it matters or not, but you might experiment with other routes of administration as well as dose to see if they make a difference. Hopefully that other post will give you some helpful ideas, too, in case it’s related.

    • WillStealYourUsernameEnglish
      3·
      6 days ago

      For me they stopped eventually, but was there constantly for a few days after each injection. I tried three different esters and thought the newest one worked because of different ingredients, but when I tried one of the previous ones again I had no pains. I dunno if it was caused by stress, if me doing more exercise or eating better helped, or really have any good explanation for what happened and why it stopped.

      I also did have some random but minor pains when I first started HRT, before I tried injections, but it was very bearable and stopped within a few weeks. To me it seemed like different kinds of pains because my body got new instructions etc, like my ligaments changing, but I don’t really know. All I know is it was just briefly now and then before stopping.

      • dandelionEnglish
        3·
        6 days ago

        sounds hopeful, yay! Glad that they eventually went away ❤️